As hypertension develops, the forces exerted by blood pressure are applied to the vessels’ structures inducing pathological changes in the cellular components of the vasculature.  These changes are well described in cell populations of the vascular tunicas intima, media, and adventitia. However, there is a gap in our knowledge of hypertension’s impact on adipocytes and their progenitors in the fourth vessel layer, the tunica adiposa or perivascular adipose tissue (PVAT). Adipocytes are the core cells Leer más…

During the periparturient period of dairy cows, adipose tissues (AT) lipolysis fulfills, in part, energy deficits driven by fetal growth and the onset of lactation. Lipolysis induces a remodeling process within AT that is characterized by a moderate inflammatory response with infiltration of macrophages. In periparturient cows that successfully transition into lactation, lipolysis rate decreases and AT inflammation resolves as lactation progresses. However, when lipolysis rate is not reduced, AT inflammation is maintained leading to Leer más…