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The perivascular adipocyte: integrating mechanical and structural cues into vasoactive function
As hypertension develops, the forces exerted by blood pressure are applied to the vessels’ structures inducing pathological changes in the cellular components of the vasculature. These changes are well described in cell populations of the vascular tunicas intima, media, and adventitia. However, there is a gap in our knowledge of […]
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Endotoxemia and the pathogenesis of lipolysis dysregulation in periparturient dairy cows.
During the periparturient period of dairy cows, adipose tissues (AT) lipolysis fulfills, in part, energy deficits driven by parturition and lactogenesis. Lipolysis induces a remodeling process within AT that is characterized by inflammation with infiltration of macrophages (ATM). In healthy cows, lipolysis rate decreases and AT inflammation resolves as lactation […]
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Oxidized linoleic acid metabolites produced during lipolysis modulate adipose tissue.
During the periparturient period of dairy cows, adipose tissues (AT) lipolysis fulfills, in part, energy deficits driven by fetal growth and the onset of lactation. Lipolysis induces a remodeling process within AT that is characterized by a moderate inflammatory response with infiltration of macrophages. In periparturient cows that successfully transition […]